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A case of colitis?

12/7/2021

Comments

 
Picture
These linear lesions were found in a 50 yr old patient undergoing colonoscopy to investigate her loose stool. 
WHAT IS THE LIKELY DIAGNOSIS?
a) Crohn's disease
Does give linear ulcers but should be larger and deeper!
b) Ischaemic colitis
Also gives linear ulceration, often on the ante-mesenteric border.
c) Collagenous colitis
Absolutely!
d) Ulcerative colitis
Doesn't give linear ulceration and surrounding mucosa wouldn't be normal
e) Lymphocytic colitis
Perhaps one could develop into the other?
explanation

Actually, this patient had collagenous colitis! I suspect that the acute injury are linear tears in the mucosa which then granulate as in the images above. Finally, you are left with linear scars as in the image below. Pure speculation but seems logical ! 

At colonoscopy, the mucosa is often unremarkable but there may also be mild, patchy erythema or linear cracks. Histology reveals the typical thickening of the subepithelial collagen layer from the normal 3-6 μm to more than 10 μm as well as lymphocytic infiltration of the epithelium and the lamina propria. 

Rectal biopsies are not sufficient to make the diagnosis as normally the collagen layer is particularly thin here.  Samples from the rectum and sigmoid confirms the diagnosis is more than 90% of cases. 

Interestingly, patients with eosinophilic oesophagitis may also develop some fibrosis in the lamina propria which also 'cracks' in a spectacular way when a dilatation is carried out.
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    Categories

    All
    Barrett's
    Cancer
    Cancer Syndromes
    Colitis
    Colorectum
    Corrosive Ingestion
    Crypt Pattern
    Difficulty: Hard
    Difficulty: Moderate
    Difficulty: Very Hard
    Duodenum
    Eosinophilic Oesophagitis
    EUS
    Foveolar Metaplasia
    Gastric
    Gastroscopy
    GI Bleeding
    Histology
    HPB
    Ileum
    Immunosuppression
    Infection
    Local Recurrence Of Barrett's Ca.
    Lymphoma
    Mixed Polyp
    Mucosal Prolapse Syndrome
    NET
    Non-lifting Sign
    Oesophagus
    Opinion Piece!
    Pharynx
    Polyp
    Polypectomy
    The Basics
    TSA

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